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A novel cell subset: Interferon-producing killer dendritic cells

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Abstract

Recent reports introduce a novel cell subset of DCs with antigenic phenotypes shared by both NK cells and B cells, but without surface markers of pDCs and T cells, appearing to be a chimera of NK cells and DCs, namely interferon-producing killer dendritic cells (IKDCs). IKDCs not only secret type I and type II interferons to recognize and kill tumor cells effectively, but also express MHC-II molecules to present antigens. Thus, IKDCs are considered as important immunosurveilance cells for tumors, providing a link between innate and adaptive immunity.

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Authors and Affiliations

  1. Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, 510632, China

    JiongKun Wang & FeiYue Xing

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  1. JiongKun Wang
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  2. FeiYue Xing
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Correspondence to FeiYue Xing.

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Supported by the National Natural Science Foundation of China (Grant No. 30471635), and Natural Science Foundation of Guangdong Province in China (Grant Nos. 04010451 and 5006033)

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Wang, J., Xing, F. A novel cell subset: Interferon-producing killer dendritic cells. SCI CHINA SER C 51, 671–675 (2008). https://doi.org/10.1007/s11427-008-0084-y

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  • DOI: https://doi.org/10.1007/s11427-008-0084-y

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