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Structure comparisons of Aedes albopictus densovirus with other parvoviruses

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Abstract

Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2-nm resolution was obtained by electron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure comparisons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity between C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other insect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses.

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Authors and Affiliations

  1. Department of Biomedical Engineering, School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, 510640, China

    Cheng LingPeng

  2. State Key Laboratory of Biocontrol, Sun Yat-sen University, Guangzhou, 510275, China

    Cheng LingPeng, Chen SenXiong & Zhang JingQiang

  3. Department of Pathology & Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, 77030, USA

    Z. H. Zhou

Authors
  1. Cheng LingPeng
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  2. Chen SenXiong
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  3. Z. H. Zhou
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  4. Zhang JingQiang
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Corresponding author

Correspondence to Zhang JingQiang.

Additional information

Supported by the National Natural Science Foundation of China (Grant No. 10274106 to Jingqiang Zhang), Welch Foundation (AU-1492 to Z. H. Zhou) and Natural Science Foundation of Guangdong Province, China (05300232 to Lingpeng Cheng)

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Cheng, L., Chen, S., Zhou, Z.H. et al. Structure comparisons of Aedes albopictus densovirus with other parvoviruses. SCI CHINA SER C 50, 70–74 (2007). https://doi.org/10.1007/s11427-007-2036-3

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  • DOI: https://doi.org/10.1007/s11427-007-2036-3

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