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Evolution of cd59 gene in mammals

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Abstract

The CD59-coding sequences were obtained from 5 mammals by PCR and BLAST, and combined with the available sequences in GenBank, the nucleotide substitution rates of mammalian cd59 were calculated. Results of synonymous and nonsynonymous substitution rates revealed that cd59 experienced negative selection in mammals overall. Four sites experiencing positive selection were found by using “site-specific” model in PAML software. These sites were distributed on the molecular surface, of which 2 sites located in the key functional domain. Furthermore, “branch-site-specific” model detected 1 positive site in cd59a and cd59b lineages which underwent accelerated evolution caused by positive selection after gene duplication in mouse.

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Authors and Affiliations

  1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China

    Gong YuanYing, Peng MinSheng, Zhou WeiPing & Zhang YaPing

  2. Graduate University of the Chinese Academy of Sciences, Beijing, 100049, China

    Gong YuanYing & Peng MinSheng

  3. Molecular and Cell Biology, University of Science and Technology of China, Hefei, 230026, China

    Zhou WeiPing

  4. Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, 650091, China

    Zhou WeiPing & Zhang YaPing

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  1. Gong YuanYing
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  2. Peng MinSheng
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  3. Zhou WeiPing
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  4. Zhang YaPing
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Correspondence to Zhang YaPing.

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These authors have the equal contribution to this paper

Supported by the National Basic Research Program of China (973 Program, Grant No. 2007CB411600), the National Natural Science Foundation of China (Grant Nos. 30621092 and 30430110), and Bureau of Science and Technology of Yunnan Province, China

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Gong, Y., Peng, M., Zhou, W. et al. Evolution of cd59 gene in mammals. SCI CHINA SER C 50, 773–779 (2007). https://doi.org/10.1007/s11427-007-0095-0

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  • DOI: https://doi.org/10.1007/s11427-007-0095-0

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