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Polymorphisms in the 5′ regulatory region of myostatin gene are associated with early growth traits in Yorkshire pigs

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Abstract

Myostatin is a negative regulator of skeletal muscle mass. The present study cloned the 5′ regulatory region of porcine myostatin gene, screened its polymorphisms and analyzed their associations with early growth traits in Yorkshire pigs. The results indicated that a fragment length polymorphism and a polymorphism concerning two nucleotide changes exist in the 5′ regulatory region of porcine myostatin gene. At sites 435 and 447, allele A and allele B have the haplotypes of A-G and G-A, respectively. The allelic frequency of B is 0.475 in Yorkshire pigs. No homozygous BB genotype was detected in 9 Laiwu Black pigs. Allele B was found to have positive effect on body weight on day 21 (BW21) (P<0.01), body weight on day 28 (BW28) (P<0.05), body weight on day 70 (BW70) (P<0.05), average daily gain from birth to 21 d (ADG1) (P<0.01), average daily gain from birth to 28 d (ADG2) (P<0.05) and average daily gain from 21 d to 70 d (ADG3) (P<0.01), respectively. The additive effect of allele B on BW21, BW28, BW70, ADG1, ADG2 and ADG3 was 0.596±0.205 kg (P=0.0041), 0.498±0.200 kg (P=0.0136), 1.409±0.551 kg (P=0.0112), 28.39±9.74 g P=0.0041), 17.78±7.15 g (P=0.0136) and 37.00±16.92 g (P=0.0304), respectively, whereas its effect on average daily gain from 28 d to 70 d (ADG4) was not significant (P>0.1), although BB individuals are superior in average daily gain to AA and AB.

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Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, 271018, China

    Yu LingZhi, Tang Hui, Zou LiLi & Jiang YunLiang

  2. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, 250100, China

    Wang JiYing & Wu Ying

  3. College of Animal Science and Technology, China Agricultural University, Beijing, 100094, China

    Wu ChangXin

  4. State Key Laboratory for Agro-biotechnology, China Agricultural University, Beijing, 100094, China

    Li Ning

Authors
  1. Yu LingZhi
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  2. Tang Hui
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  3. Wang JiYing
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  4. Wu Ying
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  5. Zou LiLi
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  6. Jiang YunLiang
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  7. Wu ChangXin
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  8. Li Ning
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Corresponding authors

Correspondence to Jiang YunLiang or Li Ning.

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Supported by the National High Technology Research and Development Program of China (863) (Grant No. 2006AA10Z1E1)

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Yu, L., Tang, H., Wang, J. et al. Polymorphisms in the 5′ regulatory region of myostatin gene are associated with early growth traits in Yorkshire pigs. SCI CHINA SER C 50, 642–647 (2007). https://doi.org/10.1007/s11427-007-0075-4

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  • DOI: https://doi.org/10.1007/s11427-007-0075-4

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