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Reversibly sensitizing-storing-releasing 1O2 within a single platinum(II)-acetylide-based metallacycle molecule via laser power modulation

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Abstract

Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy (PDT) for solid tumors, which is highly dependent on tissue oxygen concentration. In this study, we developed a platinum(II)-acetylide-based metallacycle compound bearing six 1,4-dimethylnaphthalenes (DMN) groups, and controlled the photodynamic and photothermal effects of the compound by adjusting the power of 730 nm laser to achieve reversible sensitization, storage and release of 1O2 within a single molecule. The compound formed nanoparticles by self-assembly and exhibited good water solubility and biocompatibility. Under laser irradiation, the strong spin-orbit coupling of platinum atoms in the metallacycle facilitated 1O2 generation. The produced 1O2 was captured by the DMN carriers and transported into the hypoxic tumor, where 1O2 release was triggered owing to the good photothermal effect of the extended conjugation of the metallacycle. During therapy, the metallacycle serving as a photosensitizer, 1O2 carrier, and photothermal reagent, achieved the synergistic therapy of PDT/PTT, demonstrating the versatility of the metallacycle. This study proposes a new strategy to develop phototherapy agents that are suitable for hypoxic tumors.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22075148, 22161160318), the Natural Science Foundation of Jiangsu Higher Education Institutions of China (21KJB150013) and the Youth Fund Project of Jiangsu Natural Science Foundation (BK20210583). Thanks to Kenneth Yin Zhang for his valuable suggestions on the revision of our manuscript and helped us polish our manuscript.

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Authors and Affiliations

  1. State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) & Institute of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications (NUPT), Nanjing, 210023, China

    Ruyi Zhou, Wen Lv, Bo Li, Bo Yu, Sudi Zhang, Yucheng Zhou, Shujuan Liu & Qiang Zhao

  2. College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and Devices, Nanjing University of Posts and Telecommunications (NUPT), Nanjing, 210023, China

    Qiang Zhao

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  1. Ruyi Zhou
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  2. Wen Lv
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  3. Bo Li
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  4. Bo Yu
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  5. Sudi Zhang
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  6. Yucheng Zhou
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  8. Qiang Zhao
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Correspondence to Shujuan Liu or Qiang Zhao.

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Conflict of interest The authors declare no conflict of interest.

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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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11426_2023_1836_MOESM1_ESM.docx

Reversibly sensitizing-storing-releasing 1O2 within a single platinum(II)-acetylide-based metallacycle molecule via laser power modulation

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Zhou, R., Lv, W., Li, B. et al. Reversibly sensitizing-storing-releasing 1O2 within a single platinum(II)-acetylide-based metallacycle molecule via laser power modulation. Sci. China Chem. 67, 604–611 (2024). https://doi.org/10.1007/s11426-023-1836-y

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