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Functionalization of C,C-palladacycles: application in the synthesis of functional molecules

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Abstract

Significant advancements have been achieved in the field of C,C-palladacycles functionalization in recent decades, which have greatly contributed to the synthesis of intricate drug molecules, natural products, innovative materials, and chiral ligands. Additionally, these advancements have led to the establishment of highly efficient and atom-economic synthetic processes. Based on the differences in the C–Pd bonds, C, C-palladacycles can be further classified into several main types: C(aryl), C(alkyl)-, C(aryl), C(aryl)-, C(aryl), C(vinyl)-, and C(alkyl), C(carbonyl)-palladacycles. This minireview will highlight the recent advances in the synthesis of functional molecules through the functionalization of different C,C-palladacycles, and we hope this survey will inspire future strategic developments for C,C-palladacycle catalysts and their synthetic application.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22101296) and the State Key Laboratory of Systems Medicine for Cancer (SB23-09, KF2130-93).

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Authors and Affiliations

  1. State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China

    Dong Wei

  2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China

    Guo-Qiang Lin

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  1. Dong Wei
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  2. Guo-Qiang Lin
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Correspondence to Dong Wei or Guo-Qiang Lin.

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Wei, D., Lin, GQ. Functionalization of C,C-palladacycles: application in the synthesis of functional molecules. Sci. China Chem. 66, 2721–2733 (2023). https://doi.org/10.1007/s11426-023-1758-1

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  • DOI: https://doi.org/10.1007/s11426-023-1758-1

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