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Rational design of platinum(II) complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

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Abstract

The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer chemotherapy. Herein, the mitochondria-targeted platinum(II) complexes have been prepared. The introduction of the triazole group with larger steric hindrance through post-click reaction converts the hybridization of carbon from sp to sp2, endowing the complexes with an orthogonally oriented ligand with restricted rotation and emission enhancement characteristics. Methylation of the triazolyl ligand has led to platinum(II) complexes that can efficiently enter cancer cells and selectively accumulate in mitochondria, leading to significant enhancement in phosphorescence. In vivo anti-cancer investigations have demonstrated their distinct antitumor efficacy in substantial inhibition of tumor growth in breast cancer mice through dissipation of mitochondrial membrane potential, inducing apoptosis of tumor cell with negligibly systemic cytotoxicity.

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Acknowledgements

This work was supported by Zhejiang Provincial Natural Science Foundation of China (LR22B010001, LQ23B010001), the National Natural Science Foundation of China (22201057, 21871297), the General Research Fund (GRF) grant from the Research Grants Council of the Hong Kong Special Administrative Region, People’s Republic of China (HKU17303421), the Collaborative Research Fund (CRF) (C7075-21G), Hangzhou Normal University (2021QDL001, 2021QDL065), the West Lake Scholar Plan, the Hangzhou Leading Innovation and Entrepreneurship Team Project (TD2022001), and the CAS-Croucher Funding Scheme for Joint Laboratory on Molecular Functional Materials for Electronics, Switching and Sensing. V.W.-W.Y. and Y.A. acknowledges support from Sun Yat-Sen University, The University of Hong Kong, and the Innovation Technology Commission to the State Key Laboratory of Synthetic Chemistry.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 311121, China

    Yeye Ai, Yuexuan Fei, Junqiu Liu & Yongguang Li

  2. Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong, Hong Kong, China

    Yeye Ai, Angela Sin-Yee Law & Vivian Wing-Wah Yam

  3. School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, China

    Yeye Ai, Ruirong Ye, Zong-Wan Mao, Yongguang Li & Vivian Wing-Wah Yam

  4. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China

    Zherui Zhang, Junqiu Liu & Vivian Wing-Wah Yam

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  1. Yeye Ai
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  2. Zherui Zhang
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  3. Yuexuan Fei
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Correspondence to Zong-Wan Mao, Junqiu Liu, Yongguang Li or Vivian Wing-Wah Yam.

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Conflict of interest The authors declare no conflict of interest.

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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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11426_2023_1702_MOESM1_ESM.pdf

Rational design of platinum(II) complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

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Ai, Y., Zhang, Z., Fei, Y. et al. Rational design of platinum(II) complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo. Sci. China Chem. 66, 2878–2884 (2023). https://doi.org/10.1007/s11426-023-1702-x

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  • DOI: https://doi.org/10.1007/s11426-023-1702-x

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