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Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms

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Abstract

Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1O2 generation in a biological aqueous solution. The produced 1O2 and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics.

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Acknowledgements

This work was supported by the Natural Science Foundation of Guangdong Province (2023B1515020060, 2021B1515020050), the Science and Technology Foundation of Shenzhen (RCYX20221008-092906021, JCYJ20210324095200002, JCYJ20220531103405012), the National Natural Science Foundation of China (22077085, 22177078, 22277153). We appreciate the UPLC-MS system of Shenzhen Bay Laboratory and the Instrumental Analysis Center of Shenzhen University.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China

    Yue Li, Haobing Wang & Pingyu Zhang

  2. School of Pharmaceutical Science (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China

    Huaiyi Huang

  3. Huitong School, Shenzhen, 518066, China

    Qitian Lin & Xinyu Yu

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  1. Yue Li
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  2. Haobing Wang
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Correspondence to Pingyu Zhang.

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Supporting information The supporting information is available online at https://chem.scichina.com and https://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Li, Y., Wang, H., Lin, Q. et al. Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms. Sci. China Chem. 66, 2645–2653 (2023). https://doi.org/10.1007/s11426-023-1696-5

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  • DOI: https://doi.org/10.1007/s11426-023-1696-5

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