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A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging

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Abstract

Taking apart in numerous physiological and pathological activities, hydrogen sulfide (H2S) has been selected as an excellent target spot for the early diagnosis of cancer. So far, there are many mature probes that apply single optical imaging to monitor endogenous H2S. Nevertheless, a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms. Herein, we developed a dual-modal imaging probe BWS. This designed probe showed a specific response to H2S with both chemiluminescence and NIR fluorescence light-up. The concurrence of fluorescence and chemiluminescence signal provided “double insurances” for highly accurate monitoring of H2S. Satisfactorily, this dual-modal imaging probe performed precise visualization of endogenous H2S in living cells and in vivo. We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H2S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22077030, 22271092, 21977018, 82173657), and the China Postdoctoral Science Foundation (2021M701196). We appreciate Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

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Authors and Affiliations

  1. Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China

    Xuemei Dong, Lixin Sun, Tianli Zhu, Jie Sun, Jinzhu Gao, Chengjun Dong, Rongchen Wang & Chunchang Zhao

  2. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China

    Ziwen Zhang & Xianfeng Gu

Authors
  1. Xuemei Dong
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  2. Lixin Sun
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  3. Ziwen Zhang
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  4. Tianli Zhu
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  5. Jie Sun
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  6. Jinzhu Gao
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  7. Chengjun Dong
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  8. Rongchen Wang
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  9. Xianfeng Gu
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  10. Chunchang Zhao
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Correspondence to Rongchen Wang, Xianfeng Gu or Chunchang Zhao.

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Conflict of interest The authors declare no conflict of interest.

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Supporting information The supporting information is available online at https://chem.scichina.com and https://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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11426_2023_1579_MOESM1_ESM.docx

A Dual-Modality Hydrogen Sulfide-Specific Probe Integrating Chemiluminescence with NIR Fluorescence for Targeted Cancer Imaging

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Dong, X., Sun, L., Zhang, Z. et al. A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging. Sci. China Chem. 66, 1869–1876 (2023). https://doi.org/10.1007/s11426-023-1579-y

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