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Lanthanide-oxo clusters for efficient catalytic reduction of carboxamides

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Abstract

The reduction of carboxamides into high value-added amines is a very interesting but great challenging topic. Herein we demonstrate that polynuclear lanthanide-oxo clusters Ln16 (Ln = Eu and Gd) can be used as efficient catalyst to reduce primary and secondary carboxamides to amines with excellent yield of 71%–98% and broad substrates scope. The methodology can extend to the gram-scale synthesis of phenethylamine drug with 93% yield. Based on the isolation and characterization of catalytic intermediates, a catalytic mechanism involving multipath reaction is proposed. This work provides efficient lanthanide cluster catalysts for the reduction of carboxamides to amines.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (92161104, 21871224, 92161203, 21721001).

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China

    Zhen-Zhang Weng, Chao-Long Chen, Long-Wu Ye, La-Sheng Long, Lan-Sun Zheng & Xiang-Jian Kong

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  1. Zhen-Zhang Weng
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  2. Chao-Long Chen
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  3. Long-Wu Ye
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  4. La-Sheng Long
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  6. Xiang-Jian Kong
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Correspondence to Xiang-Jian Kong.

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Conflict of interest The authors declare no conflict of interest.

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Supporting information The supporting information is available online at https://chem.scichina.com and https://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Weng, ZZ., Chen, CL., Ye, LW. et al. Lanthanide-oxo clusters for efficient catalytic reduction of carboxamides. Sci. China Chem. 66, 443–448 (2023). https://doi.org/10.1007/s11426-022-1493-y

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  • DOI: https://doi.org/10.1007/s11426-022-1493-y

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