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Electron transfer in protein modifications: from detection to imaging

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Abstract

Signal pathways participate in vital biological processes and regulate complex life activities through protein modifications. Protein modifications in signal pathways are accompanied by electron transfer. The study of electronic behavior helps to explore the physical and chemical processes in signal pathways, receiving extensive attention. There are some excellent reviews that have summarized methods for signal pathway detection, while few discussions are from an electron transfer perspective. This review describes the relationship between signal pathways and electron transfer in protein modification. Subsequently, we summarize the electron transfer-based detection methods, such as electrochemical, photoelectrochemical and electrochemiluminescence methods. Additionally, the applications of signal pathway detection in mechanism study and imaging are also reviewed. Finally, a comprehensive discussion of the summary and outlooks in this field is presented, aiming to provide valuable guidance for the molecular mechanism of life processes and the development of new analytical techniques.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22174038, 21925401, 21904037, 52221001) and the Natural Science Foundation of Hunan Province (2022JJ20005, 2020JJ4173).

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    Lei Zhang, Mengge Chu, Cailing Ji, Wenjie Wang, Jie Tan & Quan Yuan

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  3. Cailing Ji
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  4. Wenjie Wang
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  5. Jie Tan
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  6. Quan Yuan
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Correspondence to Jie Tan or Quan Yuan.

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Zhang, L., Chu, M., Ji, C. et al. Electron transfer in protein modifications: from detection to imaging. Sci. China Chem. 66, 388–405 (2023). https://doi.org/10.1007/s11426-022-1417-3

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  • DOI: https://doi.org/10.1007/s11426-022-1417-3

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