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Electrochemiluminescence biosensing and bioimaging with nanomaterials as emitters

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Abstract

The continuous emergence of novel luminophores has been leading the development of electrochemiluminescence (ECL) analysis since the ECL phenomenon of silicon nanoparticles was first reported in 2002. Nanomaterial-based luminophores termed as nanoemitters exhibit great application potential in ECL bioanalysis. In this review, we systematically summarize the research progress of various types of ECL nanoemitters, such as semiconductor quantum dots (QDs), carbon dots (CDs), polymer dots (Pdots), aggregation-induced emission nanoparticles (AIE dots), and other nanoemitters including luminophore-doped silica nanoparticles, metal-organic frameworks, covalent organic frameworks, and metal nanoclusters. We mainly emphasize the characteristic of these nanoemitters and their applications in ECL biosensing and bioimaging by using them as labels, and highlight some impressive cases in the last five years. Finally, we discuss current challenges in the field of ECL nanoemitters and point out their prospects.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21804107, 21890741, 21827812), the State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS1807), Taishan Scholars Construction Engineering (tsqn202103112), and the support plan for youth entrepreneurship and technology of colleges and universities in Shandong Province (2021KJ052). The authors also thank Zhuanzhuan Wang and Haijing Guo for literature collection.

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  1. Research Center of Analytical Instrumentation, Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, 710127, China

    Yaqiang Feng

  2. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China

    Ningning Wang & Huangxian Ju

  3. School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, China

    Ningning Wang

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  1. Yaqiang Feng
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  2. Ningning Wang
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  3. Huangxian Ju
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Correspondence to Huangxian Ju.

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Feng, Y., Wang, N. & Ju, H. Electrochemiluminescence biosensing and bioimaging with nanomaterials as emitters. Sci. China Chem. 65, 2417–2436 (2022). https://doi.org/10.1007/s11426-022-1329-5

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  • DOI: https://doi.org/10.1007/s11426-022-1329-5

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