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Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease

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Abstract

The misfolding and aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD). Here, chiral dimanganese trioxide (Mn2O3) nanoparticles (NPs) were prepared for PD treatment enhanced by a noninvasive electromagnetic field (MF). The affinity constants of D-NPs toward α-syn monomer (mono) or α-syn fibril were 3.5 times or 5.2 times higher, respectively, than those of L-NPs, and the mechanical force generated by NPs under a MF further promoted the interaction between NPs and α-syn to amplify the difference between L-NPs and D-NPs. As the synergy effect of the preferentially affinity ability and MF-induced mechanical forces, D-NPs exhibited a better inhibitory efficiency on α-syn fibrillization than L-NPs. Furthermore, after differentially cellular uptake of L-/D-NPs via the caveolin-mediated pathway, as reactive oxygen species (ROS)-scavengers, D-NPs possess higher efficiency in decreasing intracellular ROS level than L-NPs to provide higher cytoprotective efficiency to neuron cells. In vivo data showed that after treatment with D-NPs under a MF for 60 days, α-syn concentration in the cerebrospinal fluid of PD mice decreased 81%, while dopamine level in the brain of PD mice increased 2.3-fold. These findings indicated the potential of utilizing the synergic interplay of chiral NPs and MF for treating disease and opened a new path to explore the nanoscale chirality for regulating the biological effect.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (32071400, 51902136).

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Authors and Affiliations

  1. International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, 214122, China

    Xiuxiu Wang, Jing Zhao, Weiwei Wang, Meiru Lu, Aihua Qu, Maozhong Sun, Chen Chen, Hua Kuang, Chuanlai Xu & Liguang Xu

  2. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China

    Xiuxiu Wang, Jing Zhao, Weiwei Wang, Meiru Lu, Aihua Qu, Maozhong Sun, Chen Chen, Hua Kuang, Chuanlai Xu & Liguang Xu

  3. Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory, Wenzhou, 325001, China

    Xiaoqing Gao

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  1. Xiuxiu Wang
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  2. Jing Zhao
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  3. Weiwei Wang
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  4. Meiru Lu
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Correspondence to Liguang Xu.

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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Wang, X., Zhao, J., Wang, W. et al. Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease. Sci. China Chem. 65, 1911–1920 (2022). https://doi.org/10.1007/s11426-022-1321-0

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  • DOI: https://doi.org/10.1007/s11426-022-1321-0

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