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Visible-light-mediated tungsten-catalyzed C-H amination of unactivated alkanes with nitroarenes

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Abstract

Alkylamines are important motifs in pharmaceutical and material sciences. The existing reports of C-H amination are limited to ammonia, diazo and azide nitrogen sources. This work describes a rapid construction of C-N bonds from accessible nitroarene and alkane feedstock under decatungstate catalysis. A variety of C-H precursors including gaseous, linear, cyclic and benzylic hydrocarbons could adopt this protocol to afford the corresponding alkylamines in high efficiency.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21772085, 21971107, 2201101) and China Postdoctoral Science Foundation (2021T140309, 2021M691511).

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Authors and Affiliations

  1. State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China

    Qing Wang, Shengyang Ni, Xiaochen Wang, Yi Wang & Yi Pan

Authors
  1. Qing Wang
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  2. Shengyang Ni
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  3. Xiaochen Wang
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  4. Yi Wang
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  5. Yi Pan
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Correspondence to Yi Wang.

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Conflict of interest The authors declare no conflict of interest.

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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Wang, Q., Ni, S., Wang, X. et al. Visible-light-mediated tungsten-catalyzed C-H amination of unactivated alkanes with nitroarenes. Sci. China Chem. 65, 678–685 (2022). https://doi.org/10.1007/s11426-021-1170-2

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  • DOI: https://doi.org/10.1007/s11426-021-1170-2

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