Abstract
In our long-term efforts searching for antimalarial agents from Chinese medicinal plants, seven novel dimeric sesquiterpenoids (1–7) with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp. brachystachys by solid data acquired by diverse methods. Among them, compound 3 with an EC50 value of 4.3 pM against the chloroquine-resistant Plasmodium falciparum is the most potent antimalarial agent reported hitherto, about 1,000-fold stronger than artemisinin. This article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (21772212), and Biological Resources Program, Chinese Academy of Sciences (ZSTH-032). We thank Prof. S.-M Huang from the Department of Biology, Hainan University of China, for the identification of the plant material.
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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.
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Zhou, B., Zimbres, F.M., Butler, J.H. et al. Picomolar antimalarial agent from a Chinese medicinal plant. Sci. China Chem. 65, 82–86 (2022). https://doi.org/10.1007/s11426-021-1124-x
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DOI: https://doi.org/10.1007/s11426-021-1124-x