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Photoredox/palladium-cocatalyzed enantioselective alkylation of secondary benzyl carbonates with 4-alkyl-1,4-dihydropyridines

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Abstract

A photoredox/palladium-cocatalyzed enantioselective alkylation of racemic secondary carbonates with 4-alkyl-1,4-dihydropyridines under visible light irradiation has been developed. The present study provides a method for the preparation of optically active diarylalkanes from racemic diarylmethyl carbonates by a dynamic kinetic asymmetric transformation (DYKAT). This photoredox/palladium dual catalysis strategy expands the scope of the asymmetric Pd-catalyzed benzylic substitution reaction and serves as its potential alternative and complement.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21971110, 21732003).

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Authors and Affiliations

  1. State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China

    Xu Shen, Linlin Qian & Shouyun Yu

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  1. Xu Shen
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  2. Linlin Qian
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  3. Shouyun Yu
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Correspondence to Shouyun Yu.

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The authors declare that they have no conflict of interest.

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The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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11426_2019_9732_MOESM1_ESM.pdf

Photoredox/palladium-cocatalyzed enantioselective alkylation of secondary benzyl carbonates with 4-alkyl-1,4-dihydropyridines

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Shen, X., Qian, L. & Yu, S. Photoredox/palladium-cocatalyzed enantioselective alkylation of secondary benzyl carbonates with 4-alkyl-1,4-dihydropyridines. Sci. China Chem. 63, 687–691 (2020). https://doi.org/10.1007/s11426-019-9732-5

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