Abstract
Described herein is an efficient protocol for the regioselective introduction of a vinyl trifluoromethylthioether to remote unactivated C(sp3)—H bonds. The cascade process involves the vinyl radical-mediated 1,5-hydrogen atom transfer (HAT) and remote vinyl migration. During the transformation, inert C—H and C—C bonds are consecutively cleaved under mild conditions. The reaction features good functional group tolerance, broad substrate scope, and high regio-/stereo-selectivity.
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Acknowledgements
This work was supported by Soochow University, the National Natural Science Foundation of China (21722205), the Project of Scientific and Technologic Infrastructure of Suzhou (SZS201708), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.
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Regioselective Introduction of Vinyl Trifluoromethylthioether to Remote Unactivated C(sp3)-H Bonds via Radical Translocation Cascade
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Wu, S., Wu, X., Wu, Z. et al. Regioselective introduction of vinyl trifluoromethylthioether to remote unactivated C(sp3)—H bonds via radical translocation cascade. Sci. China Chem. 62, 1507–1511 (2019). https://doi.org/10.1007/s11426-019-9527-5
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DOI: https://doi.org/10.1007/s11426-019-9527-5