Science China Chemistry

, Volume 61, Issue 6, pp 656–659 | Cite as

Phosphine oxide-Sc(OTf)3 catalyzed enantioselective bromoaminocyclization of tri-substituted allyl N-tosylcarbamates



Phosphine oxide-Sc(OTf)3 catalyzed regio- and enantioselective bromoaminocyclization of tri-substituted allyl N-tosylcarbamates is described. A wide variety of optically active tertiary 5-bromo-1,3-oxazinan-2-ones can be obtained with high regio-and enantioselectivity.


asymmetric bromonation bromoaminocyclization phosphine oxide-Sc(OTf)3 5-bromo-1,3-oxazinan-2-ones 


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This work was supported by the National Natural Science Foundation of China (21632005, 21172221).

Supplementary material

11426_2017_9192_MOESM1_ESM.pdf (3 mb)
Phosphine Oxide-Sc(OTf)3 Catalyzed Enantioselective Bromoaminocyclization of tri-Substituted Allyl N-Tosylcarbamates


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xiangyu Tan
    • 1
    • 2
  • Hongjie Pan
    • 1
    • 2
  • Hua Tian
    • 1
    • 2
  • Yian Shi
    • 3
    • 4
  1. 1.Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of ChemistryChinese Academy of SciencesBeijingChina
  2. 2.University of Chinese Academy of SciencesBeijingChina
  3. 3.Institute of Natural and Synthetic Organic ChemistryChangzhou UniversityChangzhouChina
  4. 4.Department of ChemistryColorado State UniversityFort CollinsUSA

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