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Graphene nanopores toward DNA sequencing: a review of experimental aspects

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Abstract

Nanopores for DNA sequencing have drawn much attention due to their potentials to achieve amplification-free, low-cost, and high-throughput analysis of nuclei acids. The material configuration and fabrication of the nanopore has become one important consideration in the nanopore based DNA sequencing research. Among various materials, the newly emerged graphene has brought more opportunities to the development of sequencing technology because of its unique structures and properties. This review mainly focuses on the experimental aspects of graphene nanopore research including the nanopore fabrication methods and processes. Meanwhile, the challenges in the present graphene nanopore research including hydrophobicity, translocation velocity and noise are also addressed and discussed.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81471697), the Key Technology R&D Program of Hubei Province (2014BBB003), Yellow Crane Talent (Science & Technology) Program of Wuhan City and Applied Basic Research Program of Wuhan City (2016060101010044, 2016060101010048), and the Fundamental Research Funds for the Central Universities (2016YXMS253). We also thank the Analytical and Testing Center (HUST) for the help of measurement.

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  1. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics and Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China

    Wei Chen, Guo-Chang Liu, Jun Ouyang, Meng-Juan Gao, Bo Liu & Yuan-Di Zhao

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  1. Wei Chen
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Correspondence to Yuan-Di Zhao.

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Chen, W., Liu, GC., Ouyang, J. et al. Graphene nanopores toward DNA sequencing: a review of experimental aspects. Sci. China Chem. 60, 721–729 (2017). https://doi.org/10.1007/s11426-016-9016-5

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