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A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells

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Abstract

A novel coumarin-based “turn-on” fluorescent probe SS-1 was developed for selective detection of SO2 derivatives in 100% water solution among reactive sulfur species (RSS). The detection limit of the method was 91.7 nM. Moreover, the probe exhibited low cytotoxicity and was successfully applied in the imaging of endogenously generated SO2 in HeLa cells.

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Acknowledgments

This work was supported by the National Program on Key Basic Research Project of China (2012CB720603) and the National Natural Science Foundation of China (21232005, 21572147, J1103315).

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Authors and Affiliations

  1. College of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, 610064, China

    Jin Yang, Kun Li, Ji-Ting Hou, Ling-Ling Li, Kang-Kang Yu & Xiao-Qi Yu

  2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610064, China

    Chun-Yan Lu

Authors
  1. Jin Yang
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  2. Kun Li
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  3. Ji-Ting Hou
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  4. Chun-Yan Lu
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  5. Ling-Ling Li
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  6. Kang-Kang Yu
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  7. Xiao-Qi Yu
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Correspondence to Kun Li or Xiao-Qi Yu.

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Yang, J., Li, K., Hou, JT. et al. A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells. Sci. China Chem. 60, 793–798 (2017). https://doi.org/10.1007/s11426-016-0411-7

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  • DOI: https://doi.org/10.1007/s11426-016-0411-7

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