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Tracing drug release process with dual-modal hyperbranched polymer-gold nanoparticle complexes

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Abstract

Dual-modal surface enhanced Raman spectrum (SERS)-fluorescence polymer/metal hybrid complexes have been prepared for tracing drug release process in tumor cells. Firstly, the hyperbranched poly((S-(4-vinyl) benzyl S′-propyltrithiocarbonate)-co- (poly(ethylene glycol) methacrylate)) (HPVBEG) was synthesized via the combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and self-condensing vinyl polymerization (SCVP). Subsequently, the anticancer drug doxorubicin (DOX) was linked to HPVBEG via pH sensitive Schiff base bonds to form HPVBEG-g-DOX conjugates. Through aminolysis reaction, HPVBEG-g-DOX was coordinated with gold nanoparticles (GNP), resulting in the formation of HPVBEG-g-DOX/GNP complexes. In neutral condition, the HPVBEG-g-DOX/GNP complexes were stable, and DOX was bound to the surface of GNPs. Therefore, the SERS of DOX could be observed, while the fluorescence of DOX was quenched by GNPs. Under an acidic environment, DOX was released from the surface of GNPs with breakage of Schiff base bonds. Thus, the SERS signal of DOX was gradually reduced. Correspondingly, the fluorescence signal of DOX was enhanced. Through dual-modal SERS-fluorescence technique, the DOX delivery and release process was traced in tumor cells. Moreover, the viability of MCF-7 cells incubated with HPVBEG-g-DOX/GNP complexes was investigated by Cell Counting Kit-8 (CCK-8) assay. The experimental results showed that HPVBEG-g-DOX/GNP complexes had similar proliferation inhibition effect compared with free DOX. Definitely, the dual-modal SERS-fluorescence complexes for tracing drug delivery and release will have promising prospects on tumor diagnosis and therapy.

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Authors and Affiliations

  1. Shanghai Key Lab of Electrical Insulation and Thermal Aging, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

    Yuanyuan Zhuang, Dali Wang, Chunhui Yin, Hongping Deng, Mo Sun, Yue Su & Xinyuan Zhu

  2. Shanghai Institute of Quality Inspection and Technical Research, Shanghai, 201114, China

    Yuanyuan Zhuang

  3. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, 200240, China

    Lin He

Authors
  1. Yuanyuan Zhuang
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  2. Dali Wang
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  3. Chunhui Yin
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  4. Hongping Deng
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  5. Mo Sun
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  6. Lin He
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  7. Yue Su
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  8. Xinyuan Zhu
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Correspondence to Hongping Deng or Xinyuan Zhu.

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These authors contributed equally to this work.

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Zhuang, Y., Wang, D., Yin, C. et al. Tracing drug release process with dual-modal hyperbranched polymer-gold nanoparticle complexes. Sci. China Chem. 59, 1600–1608 (2016). https://doi.org/10.1007/s11426-016-0228-0

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  • DOI: https://doi.org/10.1007/s11426-016-0228-0

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