Skip to main content
SpringerLink
Log in

Rational design and functional evolution of targeted peptides for bioanalytical applications

  • Reviews
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles. In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Misasi J, Gilman MSA, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ, McLellan JS. Science, 2016, 351: 1343–1346

    Article  CAS  Google Scholar 

  2. Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. Proc Natl Acad Sci USA, 2016, 113: 3257–3262

    Article  CAS  Google Scholar 

  3. Pattenden SG, Simon JM, Wali A, Jayakody CN, Troutman J, McFadden AW, Wooten J, Wood CC, Frye SV, Janzen WP, Davis IJ. Proc Natl Acad Sci USA, 2016, 113: 3018–3023

    Article  CAS  Google Scholar 

  4. Sun H, Ren J, Qu X. Acc Chem Res, 2016, 49: 461–470

    Article  CAS  Google Scholar 

  5. Zheng J, Yang R, Shi M, Wu C, Fang X, Li Y, Li J, Tan W. Chem Soc Rev, 2015, 44: 3036–3055

    Article  CAS  Google Scholar 

  6. Park J, Jiang Q, Feng D, Mao L, Zhou HC. J Am Chem Soc, 2016, 138: 3518–3525

    Article  CAS  Google Scholar 

  7. Skwarczynski M, Toth I. Chem Sci, 2016, 7: 842–854

    Article  CAS  Google Scholar 

  8. Albericio F, Kruger HG. Future Med Chem, 2012, 4: 1527–1531

    Article  CAS  Google Scholar 

  9. Fosgerau K, Hoffmann T. Drug Discov Today, 2015, 20: 122–128

    Article  CAS  Google Scholar 

  10. Li W, Joshi M, Singhania S, Ramsey K, Murthy A. Vaccines, 2014, 2: 515–536

    Article  CAS  Google Scholar 

  11. Aruga A, Takeshita N, Kotera Y, Okuyama R, Matsushita N, Ohta T, Takeda K, Yamamoto M. J Transl Med, 2014, 12: 61–71

    Article  Google Scholar 

  12. Mahato R, Tai W, Cheng K. Adv Drug Deliver Rev, 2011, 63: 659–670

    Article  CAS  Google Scholar 

  13. Boyle AL, Woolfson DN. Chem Soc Rev, 2011, 40: 4295–4306

    Article  CAS  Google Scholar 

  14. Aina OH, Liu R, Sutcliffe JL, Marik J, Pan CX, Lam KS. Mol Pharm, 2007, 4: 631–651

    Article  CAS  Google Scholar 

  15. Gray BP, Brown KC. Chem Rev, 2014, 114: 1020–1081

    Article  CAS  Google Scholar 

  16. Pazos E, Vázquez O, Mascareñas JL, Eugenio Vázquez M. Chem Soc Rev, 2009, 38: 3348–3359

    Article  CAS  Google Scholar 

  17. Lee S, Xie J, Chen X. Chem Rev, 2010, 110: 3087–3111

    Article  CAS  Google Scholar 

  18. Tweedle MF. Acc Chem Res, 2009, 42: 958–968

    Article  CAS  Google Scholar 

  19. Wan J, Alewood PF. Angew Chem Int Ed, 2016, 55: 5124–5134

    Article  CAS  Google Scholar 

  20. Lee S, Xie J, Chen X. Biochemistry, 2010, 49: 1364–1376

    Article  CAS  Google Scholar 

  21. Wu CH, Liu IJ, Lu RM, Wu HC. J Biomed Sci, 2016, 23: 8–21

    Article  Google Scholar 

  22. Yang H, Sha W, Song P, Liu Z, Qin L, Huang X, Lu J, Wang J, Duthie MS, Xiao H, Hu Z. Appl Microbiol Biotechnol, 2016, 100: 2279–2287

    Article  CAS  Google Scholar 

  23. Yamaguchi A, Isozaki K, Nakamura M, Takaya H, Watanabe T. Sci Rep, 2016, 6: 21833

    Article  Google Scholar 

  24. Zou Q, Yang KL. Anal Biochem, 2016, 494: 4–9

    Article  CAS  Google Scholar 

  25. Liu RW, Enstrom AM, Lam KS. Exp Hematol, 2003, 31: 11–30

    Article  Google Scholar 

  26. Trinh TB, Upadhyaya P, Qian Z, Pei D. ACS Comb Sci, 2016, 18: 75–85

    Article  CAS  Google Scholar 

  27. Liang X, Vézina-Dawod S, Bédard F, Porte K, Biron E. Org Lett, 2016, 18: 1174–1177

    Article  CAS  Google Scholar 

  28. Lee S, Glover MS, Reilly JP, Clemmer DE. Anal Chem, 2015, 87: 9384–9388

    Article  CAS  Google Scholar 

  29. Pelay-Gimeno M, Glas A, Koch O, Grossmann TN. Angew Chem Int Ed, 2015, 54: 8896–8927

    Article  CAS  Google Scholar 

  30. Smith LC, Leach DG, Blaylock BE, Ali OA, Urbach AR. J Am Chem Soc, 2015, 137: 3663–3669

    Article  CAS  Google Scholar 

  31. Urbach AR, Ramalingam V. Isr J Chem, 2011, 51: 664–678

    Article  CAS  Google Scholar 

  32. Miller AD. Expert Opin on Biol Therapy, 2015, 15: 245–267

    Article  CAS  Google Scholar 

  33. Zhao R, Yu X, Liu H, Zhai L, Xiong S, Su T, Liu G. J Chromatogr A, 2001, 913: 421–428

    Article  CAS  Google Scholar 

  34. Luo J, Zhang Q, Huang Y, Liu G, Zhao R. Anal Chim Acta, 2007, 590: 91–97

    Article  CAS  Google Scholar 

  35. Huang Y, Zhao R, Fu Y, Zhang Q, Xiong S, Li L, Zhou R, Liu G, Chen Y. ChemBioChem, 2011, 12: 1209–1215

    Article  CAS  Google Scholar 

  36. Zhao R, Fang C, Yu X, Liu Y, Luo J, Shangguan D, Xiong S, Su T, Liu G. J Chromatogr A, 2005, 1064: 59–66

    Article  CAS  Google Scholar 

  37. Huang Y, Zhao R, Luo J, Xiong S, Shangguan D, Zhang H, Liu G, Chen Y. J Mol Recognit, 2008, 21: 122–131

    Article  CAS  Google Scholar 

  38. Menegatti S, Zakrewsky M, Kumar S, De Oliveira JS, Muraski JA, Mitragotri S. Adv Healthcare Mater, 2016, 5: 602–609

    Article  CAS  Google Scholar 

  39. Kinoshita T, Sugiyama H, Mori Y, Takahashi N, Tomonaga A. Bioorg Med Chem Lett, 2016, 26: 955–958

    Article  CAS  Google Scholar 

  40. Zhang B, Wang B, Morales AW, Scudder J, Bhattacharyya MK, Ye JY. Anal Chem, 2016, 88: 3024–3030

    Article  CAS  Google Scholar 

  41. Maaty WS, Weis DD. J Am Chem Soc, 2016, 138: 1335–1343

    Article  CAS  Google Scholar 

  42. Wang W, Wang Z, Bu X, Li R, Zhou M, Hu Z. Adv Healthcare Mater, 2015, 4: 2802–2808

    Article  CAS  Google Scholar 

  43. Tjhung KF, Kitov PI, Ng S, Kitova EN, Deng L, Klassen JS, Derda R. J Am Chem Soc, 2016, 138: 32–35

    Article  CAS  Google Scholar 

  44. Duffy DC, Gillis HL, Lin J, Sheppard NF, Kellogg GJ. Anal Chem, 1999, 71: 4669–4678

    Article  CAS  Google Scholar 

  45. Wang W, Huang Y, Liu J, Xie Y, Zhao R, Xiong S, Liu G, Chen Y, Ma H. Lab Chip, 2011, 11: 929–935

    Article  CAS  Google Scholar 

  46. Wang W, Huang Y, Jin Y, Liu G, Chen Y, Ma H, Zhao R. Analyst, 2013, 138: 2890–2896

    Article  CAS  Google Scholar 

  47. Wang J, Liu Y, Teesalu T, Sugahara KN, Kotamrajua VR, Adams JD, Ferguson BS, Gong Q, Oh SS, Csordas AT, Cho M, Ruoslahti E, Xiao Y, Soh HT. Proc Natl Acad Sci, 2011, 108: 6909–6914

    Article  CAS  Google Scholar 

  48. Nim S, Jeon J, Corbi-Verge C, Seo MH, Ivarsson Y, Moffat J, Tarasova N, Kim PM. Nat Chem Biol, 2016, 12: 275–281

    Article  CAS  Google Scholar 

  49. Bürck J, Wadhwani P, Fanghänel S, Ulrich AS. Acc Chem Res, 2016, 49: 184–192

    Article  Google Scholar 

  50. Kenngott EE, Cole S, Hein WR, Hoffmann U, Lauer U, Maass D, Moore L, Pfeil J, Rosanowski S, Shoemaker CB, Umair S, Volkmer R, Hamann A, Pernthaner A. Mol Pharm, 2016, 13: 202–210

    Article  CAS  Google Scholar 

  51. Hosseinkhani H, Hong PD, Yu DS. Chem Rev, 2013, 113: 4837–4861

    Article  CAS  Google Scholar 

  52. Hauser CAE, Maurer-Stroh S, Martins IC. Chem Soc Rev, 2014, 43: 5326–5345

    Article  CAS  Google Scholar 

  53. Li S, Mehta AK, Sidorov AN, Orlando TM, Jiang Z, Anthony NR, Lynn DG. J Am Chem Soc, 2016, 138: 3579–3586

    Article  CAS  Google Scholar 

  54. Liu X, Marrakchi M, Xu D, Dong H, Andreescu S. Biosens Bioelectron, 2016, 80: 9–16

    Article  CAS  Google Scholar 

  55. Kaba HEJ, Pölderl A, Bilitewski U. Anal Chem, 2015, 87: 8629–8633

    Article  CAS  Google Scholar 

  56. Chen Q, Guo Y. ACS Infect Dis, 2016, 2: 187–193

    Article  CAS  Google Scholar 

  57. Lim SK, Chen P, Lee FL, Moochhala S, Liedberg B. Anal Chem, 2015, 87: 9408–9412

    Article  CAS  Google Scholar 

  58. Liu H, Zeng F, Zhang M, Huang F, Wang J, Guo J, Liu C, Wang H. J Control Release, 2016, 226: 124–137

    Article  CAS  Google Scholar 

  59. Medina SH, Miller SE, Keim AI, Gorka AP, Schnermann MJ, Schneider JP. Angew Chem Int Ed, 2016, 55: 3369–3372

    Article  CAS  Google Scholar 

  60. Li M, Tao Y, Shu Y, La Rochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR. J Am Chem Soc, 2015, 137: 14084–14093

    Article  CAS  Google Scholar 

  61. Farrokhi V, Bajrami B, Nemati R, McShane AJ, Rueckert F, Wells B, Yao X. Anal Chem, 2015, 87: 8603–8607

    Article  CAS  Google Scholar 

  62. Chang Y, Liu Z, Zhang Y, Galior K, Yang J, Salaita K. J Am Chem Soc, 2016, 138: 2901–2904

    Article  CAS  Google Scholar 

  63. Han K, Lei Q, Wang SB, Hu JJ, Qiu WX, Zhu JY, Yin WN, Luo X, Zhang XZ. Adv Funct Mater, 2015, 25: 2961–2971

    Article  CAS  Google Scholar 

  64. Liu K, Xing R, Zou Q, Ma G, Möhwald H, Yan X. Angew Chem Int Ed, 2016, 55: 3036–3039

    Article  CAS  Google Scholar 

  65. Huang Y, Hu F, Zhao R, Zhang G, Yang H, Zhang D. Chem Eur J, 2014, 20: 158–164

    Article  CAS  Google Scholar 

  66. Hu F, Huang Y, Zhang G, Zhao R, Yang H, Zhang D. Anal Chem, 2014, 86: 7987–7995

    Article  CAS  Google Scholar 

  67. Jin Y, Huang Y, Yang H, Liu G, Zhao R. Chem Commun, 2015, 51: 14454–14457

    Article  CAS  Google Scholar 

  68. Field LD, Delehanty JB, Chen YC, Medintz IL. Acc Chem Res, 2015, 48: 1380–1390

    Article  CAS  Google Scholar 

  69. An D, Su J, Weber JK, Gao X, Zhou R, Li J. J Am Chem Soc, 2015, 137: 8412–8418

    Article  CAS  Google Scholar 

  70. Song C, Zhong Y, Jiang X, Peng F, Lu Y, Ji X, Su Y, He Y. Anal Chem, 2015, 87: 6718–6723

    Article  CAS  Google Scholar 

  71. Callmann CE, Barback CV, Thompson MP, Hall DJ, Mattrey RF, Gianneschi NC. Adv Mater, 2015, 27: 4611–4615

    Article  CAS  Google Scholar 

  72. Vance D, Martin J, Patke S, Kane RS. Adv Drug Deliver Rev, 2009, 61: 931–939

    Article  CAS  Google Scholar 

  73. Zhang X, Zhang Z, Xu X, Li Y, Li Y, Jian Y, Gu Z. Angew Chem Int Ed, 2015, 54: 4289–4294

    Article  CAS  Google Scholar 

  74. Chu DSH, Bocek MJ, Shi J, Ta A, Ngambenjawong C, Rostomily RC, Pun SH. J Control Release, 2015, 205: 155–161

    Article  CAS  Google Scholar 

  75. Valldorf B, Fittler H, Deweid L, Ebenig A, Dickgiesser S, Sellmann C, Becker J, Zielonka S, Empting M, Avrutina O, Kolmar H. Angew Chem Int Ed, 2016, 55: 5085–5089

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Yanyan Huang, Yulong Jin & Rui Zhao

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yanyan Huang, Yulong Jin & Rui Zhao

Authors
  1. Yanyan Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yulong Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rui Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rui Zhao.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, Y., Jin, Y. & Zhao, R. Rational design and functional evolution of targeted peptides for bioanalytical applications. Sci. China Chem. 59, 1250–1257 (2016). https://doi.org/10.1007/s11426-016-0186-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-016-0186-x

Keywords

Search

Navigation