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Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I2: synthesis of [2,3]-fused indoline tetrahydropyridazines

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Abstract

A convergent construction of [2,3]-fused indoline tetrahydropyridazines via an I2/tert-butyl hydroperoxide (TBHP) catalyzed three-component dearomative oxidative coupling of indoles, hydrazines and acetophenone was established in moderate to good yields. This protocol provides a new approach for the synthesis of these biologically interesting fused indolines.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Molecular Recognition and Function; Institute of Chemistry, Chinese Academy of Sciences Beijing, Beijing, 100190, China

    Feng Wei, Liang Cheng, Hongyan Huang, Jiejie Liu, Dong Wang & Li Liu

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Feng Wei, Hongyan Huang & Jiejie Liu

Authors
  1. Feng Wei
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  2. Liang Cheng
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  3. Hongyan Huang
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  4. Jiejie Liu
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  5. Dong Wang
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  6. Li Liu
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Corresponding authors

Correspondence to Liang Cheng or Li Liu.

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11426_2016_170_MOESM1_ESM.pdf

Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2: Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines

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Wei, F., Cheng, L., Huang, H. et al. Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I2: synthesis of [2,3]-fused indoline tetrahydropyridazines. Sci. China Chem. 59, 1311–1316 (2016). https://doi.org/10.1007/s11426-016-0170-8

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  • DOI: https://doi.org/10.1007/s11426-016-0170-8

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