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Modification of polyfluorene nanoparticles via inclusion complexation based on cyclodextrin for lectin sensing and cell imaging

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Abstract

Currently, conjugated polymer nanoparticles are widely used with many biological applications, especially bio-imaging and labeling. Thus their modification with different biomacromolecules becomes a crucial step before various applications. In literature, this modification was normally performed via covalent bonds. To our best knowledge, modification based on inclusion complexation has not been reported. Herein, via host-guest interaction between cyclodextrin and adamantane, supramolecular modification to conjugated polyfluorene nanoparticles has been successfully achieved. The glycopolymer-modified conjugated polymer nanoparticles showed excellent binding ability to lectins, such as Galectin-3 and selective imaging behavior to Hep G2 cells.

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Authors and Affiliations

  1. Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China

    Pengfei Sun

  2. State Key Laboratory of Molecular Engineering of Polymers; Department of Macromolecular Science, Fudan University, Shanghai, 200433, China

    Pengfei Sun, Mingchang Lin, Guosong Chen & Ming Jiang

Authors
  1. Pengfei Sun
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  2. Mingchang Lin
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  3. Guosong Chen
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  4. Ming Jiang
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Correspondence to Guosong Chen.

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Sun, P., Lin, M., Chen, G. et al. Modification of polyfluorene nanoparticles via inclusion complexation based on cyclodextrin for lectin sensing and cell imaging. Sci. China Chem. 59, 1616–1620 (2016). https://doi.org/10.1007/s11426-016-0117-5

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  • DOI: https://doi.org/10.1007/s11426-016-0117-5

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