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Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction

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Abstract

Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson’s disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of α-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.

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Authors and Affiliations

  1. Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China

    Lu Wang, Xiaoming Li, Wenfeng Wang, Chunhai Fan & Nan Chen

  2. School of Life Science, Sichuan University, Chengdu, 610064, China

    Yuping Han, Ting Wang & Yun Zhao

  3. Chemistry Department, King Saud University, Riyadh, 11451, Saudi Arabia

    Aldalbahi Ali & Nahed Nasser El-Sayed

  4. School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China

    Xiaoming Li

  5. UCB Pharma, Slough, SL1 3WE, UK

    Jiye Shi

Authors
  1. Lu Wang
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  2. Xiaoming Li
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  3. Yuping Han
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  4. Ting Wang
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  5. Yun Zhao
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  6. Aldalbahi Ali
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  7. Nahed Nasser El-Sayed
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  8. Jiye Shi
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  9. Wenfeng Wang
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  10. Chunhai Fan
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  11. Nan Chen
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Corresponding authors

Correspondence to Yun Zhao or Nan Chen.

Additional information

These authors contributed equally to this work.

Electronic supplementary material

11426_2016_103_MOESM1_ESM.doc

Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction

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Wang, L., Li, X., Han, Y. et al. Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction. Sci. China Chem. 59, 1486–1491 (2016). https://doi.org/10.1007/s11426-016-0103-7

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  • DOI: https://doi.org/10.1007/s11426-016-0103-7

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