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Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population

Abstract

This study examined the total arsenic (Ast) and inorganic arsenic (Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry (ICP-MS) and high performance liquid chromatography (HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. Exposure assessment to Asi in polished rice has been calculated for the margin of exposure (MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern.

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References

  1. Chatterjee D, Halder D, Majumder S, Biswas A, Nath B, Bhattacharya P, Bhowmicka S, Mukherjee-Goswamia A, Sahaa D, Hazraa R, Maityd P, Chatterjeee D, Mukherjeef A, Bundschuh J. Assessment of arsenic exposure from groundwater and rice in Bengal Delta Region, West Bengal, India. Water Res, 2010, 44:5803–5812

    Article  CAS  Google Scholar 

  2. Breslow N, Day N. Statistical Methods in Cancer Research. Vol. 2. Lyon: IARC, 1987

    Google Scholar 

  3. Chen CJ, Wang CJ. Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res, 1990, 50:5470–5474

    CAS  Google Scholar 

  4. Chen GQ, Zhou L, Styblo M, Walton F, Jing Y, Weinberg R, Chen Z, Waxman S. Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. Cancer Res, 2003, 63:1853–1859

    CAS  Google Scholar 

  5. Nishikawa T, Wanibuchi H, Ogawa M, Kinoshita A, Morimura K, Hiroi T, Funae Y, Kishida H, Nakae D, Fukushima S. Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism. Int J Cancer, 2002, 100:136–139

    Article  CAS  Google Scholar 

  6. Gallagher PA, Wei X, Shoemaker JA, Brockhoff CA, Creed JT. Detection of arsenosugars from kelp extracts via IC-electrospray ionization-MS-MS and IC membrane hydride generation ICP-MS. J Anal At Spectrom, 1999, 14:1829–1834

    Article  CAS  Google Scholar 

  7. Meharg AA, Lombi E, Williams PN, Scheckel KG, Feldmann J, Raab AZ, Zhu Y, Islam R. Speciation and localization of arsenic in white and brown rice grains. Environ Sci Techno, 2008, 42:1051–1057

    Article  CAS  Google Scholar 

  8. Schoof R, Yost L, Eickhoff J, Crecelius E, Cragin D, Meacher D, Menzel D. A market basket survey of inorganic arsenic in food. Food Chem Toxicol, 1999, 37:839–846

    Article  CAS  Google Scholar 

  9. Tao SSH, Bolger PM. Dietary arsenic intakes in the United States: FDA total diet study, September 1991–December 1996. Food Addit Contam, 1999, 16:465–472

    Article  CAS  Google Scholar 

  10. Heitkemper DT, Vela NP, Stewart KR, Westphal CS. Determination of total and speciated arsenicin rice by ion chromatography and inductively coupled plasma mass spectrometry. J Anal At Spectrom, 2001, 16:299–306

    Article  CAS  Google Scholar 

  11. Smith NM, Lee R, Heitkemper DT, DeNicola Cafferky K, Haque A, Henderson AK. Inorganic arsenic in cooked rice and vegetables from Bangladeshi households. Sci Total Environ, 2006, 370:294–301

    Article  CAS  Google Scholar 

  12. Williams P, Price A, Raab A, Hossain S, Feldmann J, Meharg A. Variation in arsenic speciation and concentration in paddy rice related to dietary exposure. Environ Sci Technol, 2005, 39:5531–5540

    Article  CAS  Google Scholar 

  13. Abedin, MJ, Feldmann J, Meharg AA. Uptake kinetics of arsenic species in rice plants. Plant Physiol, 2002, 128:1120–1128

    Article  CAS  Google Scholar 

  14. Bednar A, Garbarino J, Ranville J, Wildeman T. Presence of organoarsenicals used in cotton production in agricultural water and soil of the southern United States. J Agric Food Chem, 2002, 50:7340–7344

    Article  CAS  Google Scholar 

  15. Lee JS, Lee SW, Chon HT, Kim KW. Evaluation of human exposure to arsenic due to rice ingestion in the vicinity of abandoned Myungbong Au-Ag mine site, Korea. J Geochem Explorat, 2008, 96:231–235

    Article  CAS  Google Scholar 

  16. Marin A, Masscheleyn P, Patrick W. The influence of chemical form and concentration of arsenic on rice growth and tissue arsenic concentration. Plant Soil, 1992, 139:175–183

    Article  CAS  Google Scholar 

  17. Odanaka Y, Tsuchiya N, Matano O, Goto S. Characterization of arsenic metabolites in rice plant treated with DSMA (disodium methanearsonate). J Agric Food Chem, 1985, 33:757–763

    Article  CAS  Google Scholar 

  18. Williams P, Raab A, Feldmann J, Meharg A. Market basket survey shows elevated levels of As in South Central US processed rice compared to California: consequences for human dietary exposure. Environ Sci Technol, 2007, 41:2178–2183

    Article  CAS  Google Scholar 

  19. Li Y. Research and practice of water-saving irrigation for rice in China. In: Barker R, Loeve R, Li YH, Tuong TP, Eds. Water-Saving Irrigation for Rice: Proceedings of an International Workshop Held in Wuhan, China. Wuhan: International Water Management Institure, 2011. 23–25

    Google Scholar 

  20. Lin HT, Wong SS, Li GC. Heavy metal content of rice and shellfish in Taiwan. J Food Drug Anal, 2004, 12:167–174

    CAS  Google Scholar 

  21. The National Bureau of Statistics. National food production Gazette (in Chinese). http://www.gov.cn/gzdt/2011-12/02/content2008844.htm. 2011-12-02

  22. Zhu YG, Sun GX, Lei M, Teng M, Liu YX, Chen NC, Wang LH, Carey AM, Deacon C, Raab A, Meharg AA, Williams PN. High percentage inorganic arsenic content of mining impacted and nonimpacted Chinese rice. Environ Sci Technol, 2008, 42:5008–5013

    Article  CAS  Google Scholar 

  23. Cheng W, Zhang G, Yao H, Dominy P, Wu W, Wang R. Possibility of predicting heavy-metal contents in rice grains based on DTPA-extracted levels in soil. Commun Soil Sci Plant Anal, 2004, 35:2731–2745

    Article  CAS  Google Scholar 

  24. Huang RQ, Gao SF, Wang WL, Staunton S, Wang G. Soil arsenic availability and the transfer of soil arsenic to crops in suburban areas in Fujian Province, southeast China. Sci Total Environ, 2006, 368:531–541

    Article  CAS  Google Scholar 

  25. Li G, Sun GX, Williams PN, Nunes L, Zhu YG. Inorganic arsenic in Chinese food and its cancer risk. Environ Int, 2011, 37:1219–1225

    Article  CAS  Google Scholar 

  26. World Health Organization. Guidelines for Drinking-Water Quality. 3 ed. Geneva: WHO, 2006. p488–493

    Google Scholar 

  27. Juhasz AL, Smith E, Weber J, Rees M, Rofe A, Kuchel T, Sansom L, Naidu R. In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Environ Health Perspect, 2006, 114:1826–1831

    CAS  Google Scholar 

  28. Yang XG, Zhai FY. The Second China National Nutrition and Health Survey Report: Diet and Nutrient Intake Status in 2002. Beijing: People’s Medical Publishing House, 2006

    Google Scholar 

  29. Batista BL, Souza JMO, De Souza SS, Barbosa F. Speciation of arsenic in rice and estimation of daily intake of different arsenic species by Brazilians through rice consumption. J Hazard Mater, 2011, 191:342–348

    Article  CAS  Google Scholar 

  30. D’Amato M, Forte G, Caroli S. Identification and quantification of major species of arsenic in rice. J AOAC Int, 2004, 87:238–243

    Google Scholar 

  31. Sanz E, Munoz-Olivas R, Camara C, Sengupta MK, Ahamed S. Arsenic speciation in rice, straw, soil, hair and nails samples from the arsenic-affected areas of Middle and Lower Ganga plain. J Environ Sci Health A, 2007, 42:1695–1705

    Article  CAS  Google Scholar 

  32. FAPAS. Protocol for Proficiency Testing Schemes. 2 ed. Sand Hutton, YORK: Fera Science Ltd., 2010

    Google Scholar 

  33. Liang F, Li Y, Zhang G, Tan M, Lin J, Liu W, Li Y, Lu W. Total and speciated arsenic levels in rice from China. Food Addit Contam, 2010, 27:810–816

    Article  CAS  Google Scholar 

  34. Ministry of Health. National Food Safety Standard Maximum Levels of Contaminants in Food. GB 2762-2012. Beijing: Standards Press of China, 2012

    Google Scholar 

  35. Heinemann R, Fagundes P, Pinto E, Penteado M, Lanfer-Marquez U. Comparative study of nutrient composition of commercial brown, parboiled and milled rice from Brazil. J Food Comp Anal, 2005, 18:287–296

    Article  CAS  Google Scholar 

  36. Codex Committee on Contaminants in Foods. Discussion Paper on Arsenic in Rice. Codex Committee on Contaminants in Foods, 5 th Session. CX/CF/11/5/10. Hague, Netherlands, 2011

    Google Scholar 

  37. Codex Committee on Contaminants in Foods. Proposed Draft Maximum Levels for Arsenic in Rice. Codex Committee on Contaminants in Foods, 6 th Session. CX/CF/12/6/8, 2012

    Google Scholar 

  38. Codex Committee on Contaminants in Foods. Proposed Draft Maximum Levels for Arsenic in Rice (Raw and Polished Rice). Codex Committee on Contaminants in Foods, 8th Session. CX/CF/14/8/6, 2014

    Google Scholar 

  39. EFSA. Scientific Opinion on Arsenic in Food. EFSA Panel on Contaminants in the Food Chain (CONTAM), 2009:1351–1550

    Google Scholar 

  40. World Health Organization. Evaluation of certain food additives and contaminants in food. Seventy-second report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series. Rome, 2011

    Google Scholar 

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Correspondence to Yongning Wu.

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Li, X., Xie, K., Yue, B. et al. Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population. Sci. China Chem. 58, 1898–1905 (2015). https://doi.org/10.1007/s11426-015-5443-5

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  • DOI: https://doi.org/10.1007/s11426-015-5443-5

Keywords

  • arsenic speciation
  • exposure assessment
  • inorganic arsenic
  • rice