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Proteomic profiling of protein corona formed on the surface of nanomaterial

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  • Special Topic Analytical Sciences at the Nano-Bio Interface
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Abstract

The formation of protein coronas on nanomaterial will significantly alter the surface properties of nanomaterial in biological systems and subsequently impact biological responses including signaling, cellular uptake, transport, and toxicity etc. It is of critical importance to understand the formation of protein coronas on the surface of nanomaterial. Analytical techniques, especially mass spectrometry-based proteomics methods, are playing a key role for the qualitative and quantitative analyses of protein coronas on nanomaterial. In this review, the proteomic approaches developed for the characterization of protein coronas on various nanomaterials are introduced with the emphasis on the mass spectrometry-based proteomic strategies.

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  1. CAS Key Laboratory of Separation Science for Analytical Chemistry; National Chromatographic R & A Center; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China

    Hongyan Zhang & Ren’an Wu

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Hongyan Zhang

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  1. Hongyan Zhang
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Correspondence to Ren’an Wu.

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Zhang, H., Wu, R. Proteomic profiling of protein corona formed on the surface of nanomaterial. Sci. China Chem. 58, 780–792 (2015). https://doi.org/10.1007/s11426-015-5395-9

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