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Iron-catalyzed aerobic oxidative amidation of tertiary amines with carboxylic acids

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Abstract

An oxidative amidation of tertiary amines with carboxylic acids has been developed in the presence of FeCl3·6H2O as catalyst and oxygen as oxidant. A variety of tertiary amides were obtained in good to excellent yields from inexpensive and readily available reagents. The possible reaction pathways were investigated.

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Authors and Affiliations

  1. Department of Chemistry, Renmin University of China, Beijing, 100872, China

    Lina Ma, Yuanming Li & Zhiping Li

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  1. Lina Ma
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  2. Yuanming Li
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  3. Zhiping Li
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Correspondence to Zhiping Li.

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Ma, L., Li, Y. & Li, Z. Iron-catalyzed aerobic oxidative amidation of tertiary amines with carboxylic acids. Sci. China Chem. 58, 1310–1315 (2015). https://doi.org/10.1007/s11426-015-5368-z

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  • DOI: https://doi.org/10.1007/s11426-015-5368-z

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