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Simultaneous acquisition of multi-nuclei enhanced NMR/MRI by solution-state dynamic nuclear polarization

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  • SPECIAL TOPIC · New Researches of State Key Laboratories in Analytical Chemistry
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Abstract

Dynamic nuclear polarization (DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance (NMR) of various molecules. Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarization of all kinds of nuclei in the system. The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy (MRS) and image (MRI). Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority. We have observed very large simultaneous DNP enhancements for different nuclei, such as 1H and 23Na, 1H and 31P, 19F and 31P, especially for the first time to report sodium ion enhancement in liquid. We have also obtained the simultaneous images of 19H and 31P, 19F and 31P at low field by solution-state DNP for the first time.

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References

  1. Pedersen JB, Freed JH. J Chem Phys, 1973, 58: 2746–2762

    Article  Google Scholar 

  2. Matysik J, Diller A, Roy E, Alia A. Photosynth Res, 2009, 102: 427–435

    Article  CAS  Google Scholar 

  3. Bowers CR, Weitekamp DP. J Am Chem Soc, 1987, 109: 5541–5542

    Article  CAS  Google Scholar 

  4. Duckett SB, Colebrooke SA. Parahydrogen Enhanced NMR Spectroscopic Methods: A Chemical Perspective. In: Grant DM, Harris RK, Eds. Encyclopedia of Nuclear Magnetic Resonance. Vol. 9. Chichester: John Wiley & Sons, Ltd, 2002. 598–606

    CAS  Google Scholar 

  5. Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer Jr CS, Wishnia A. Nature, 1994, 370: 199–201

    Article  CAS  Google Scholar 

  6. Wong-Foy A, Saxena S, Moul AJ, Bitter HL, Seeley JA, McDermott R, Clarke J, Pines A. J Magn Reson, 2002, 157: 235–241

    Article  CAS  Google Scholar 

  7. Overhauser AW. Phys Rev, 1953, 92: 411–415

    Article  CAS  Google Scholar 

  8. Goertz ST. Nucl Instrum Meth A, 2004, 526: 28–42

    Article  CAS  Google Scholar 

  9. Golman K, Zandt R, Thaning M. Proc Natl Acad Sci USA, 2006, 103: 11270–11275

    Article  CAS  Google Scholar 

  10. Gallagher FA, Kettunen MI, Day SE, Hu DE, Ardenkjær-Larsen JH, Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM. Nature, 2008, 453: 940–944

    Article  CAS  Google Scholar 

  11. Krummenacker JG, Denysenkov VP, Terekhov M, Schreiber LM, Prisner TF. J Magn Reson, 2012, 215: 94–99

    Article  CAS  Google Scholar 

  12. Hou T, MacNamara E, Raftery D. Anal Chim Acta, 1999, 400: 297–305

    Article  CAS  Google Scholar 

  13. Deshmane A, Gulani V, Griswold MA, Seiberlich N. J Magn Reson Imaging, 2012, 36: 55–72

    Article  Google Scholar 

  14. Kupce E, Freeman R, John BK. J Am Chem Soc, 2006, 128: 9606–9607

    Article  CAS  Google Scholar 

  15. Kupče Ē. NMR with multiple receivers. In: Heise H, Ed. Modern NMR Methodology. Berlin Heidelberg: Springer, 2013. 71–96

  16. Reddy JG, Hosur RV. J Biomol NMR, 2013, 56: 77–84

    Article  CAS  Google Scholar 

  17. Kupče Ē, Freeman R. Magn Reson Chem, 2010, 48: 333–336

    Google Scholar 

  18. Kupce E, Freeman R. J Magn Reson, 2010, 206: 147–153

    Article  CAS  Google Scholar 

  19. Abragam A. Phys Rev, 1965, 98: 1729–1735

    Article  Google Scholar 

  20. Hwang CF, Hill DA. Phys Rev Lett, 1967, 18: 110–112

    Article  CAS  Google Scholar 

  21. Borghini M. Phys Rev Lett, 1968, 20: 419–421

    Article  CAS  Google Scholar 

  22. Armstrong BD, Han S. J Chem Phys, 2007, 127: 104508

    Article  Google Scholar 

  23. He YG, Feng JW, Zhang Z, Wang C, Wang D, Chen F, Liu ML, Liu CY. Rev Sci Instrum, 2015, 86: 083101

    Article  Google Scholar 

  24. Potenza JA, Poindexter EH, Caplan PJ, Dwekl RA. J Am Chem Soc, 1969, 91: 4356–4360

    Article  CAS  Google Scholar 

  25. Wetterling F, Tabbert M, Junge S, Gallagher L, Macrae IM, Fagan AJ. Phys Med Biol, 2010, 55: 7681–7695

    Article  Google Scholar 

  26. Chen H, Viel S, Ziarelli F, Peng L. Chem Soc Rev, 2013, 42: 7971–7982

    Article  CAS  Google Scholar 

  27. Bentum PJM, Heijden GHA, Villanueva-Garibay JA, Kentgens APM. Phys Chem Chem Phys, 2011, 13: 17831–17840

    Article  Google Scholar 

  28. Giraudeau P, Frydman L. Annu Rev Anal Chem, 2014, 7: 129–161

    Article  CAS  Google Scholar 

  29. Kupce E, Nishida T, Freeman R. Prog Nucl Mag Res Sp, 2003, 42: 95–122

    Article  CAS  Google Scholar 

  30. Lescop E, Schanda P, Rasia R, Brutscher B. J Am Chem Soc, 2007, 129: 2756–2757

    Article  CAS  Google Scholar 

  31. Kupce E, Kay LE, Freeman R. J Am Chem Soc, 2010, 132: 18008–18011

    Article  CAS  Google Scholar 

  32. Prandolini MJ, Denysenkov VP, Gafurov M, Endeward B, Prisner TF. J Am Chem Soc, 2009, 131: 6090–6092

    Article  CAS  Google Scholar 

  33. Griffin RG, Prisner TF. Phys Chem Chem Phys, 2010, 12: 5737–5740

    Article  CAS  Google Scholar 

  34. Loening NM, Rosay M, Weis V, Griffin RG. J Am Chem Soc, 2002, 124: 8808–8809

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics; Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China

    Yugui He, Zhen Zhang, Jiwen Feng, Chongyang Huang, Fang Chen, Chaoyang Liu & Maili Liu

  2. School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China

    Yugui He & Chaoyang Liu

  3. University of Chinese Academy of Sciences, Beijing, 100048, China

    Zhen Zhang

Authors
  1. Yugui He
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  2. Zhen Zhang
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  3. Jiwen Feng
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  4. Chongyang Huang
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  5. Fang Chen
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  6. Chaoyang Liu
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  7. Maili Liu
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Correspondence to Jiwen Feng or Chaoyang Liu.

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He, Y., Zhang, Z., Feng, J. et al. Simultaneous acquisition of multi-nuclei enhanced NMR/MRI by solution-state dynamic nuclear polarization. Sci. China Chem. 59, 830–835 (2016). https://doi.org/10.1007/s11426-015-0512-0

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  • DOI: https://doi.org/10.1007/s11426-015-0512-0

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