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Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides

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Abstract

The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant, the reaction provided N,N-dialkylamides or N-alkylamides with moderate yields via multiple sp3 C-H bonds activation of methylarenes in aqueous and metal-free conditions.

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210097, China

    BingNan Du & PeiPei Sun

  2. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing, 210023, China

    PeiPei Sun

Authors
  1. BingNan Du
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  2. PeiPei Sun
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Correspondence to PeiPei Sun.

Additional information

Dedicated to Professor Qian Changtao on the occasion of his 80th birthday.

SUN PeiPei obtained his BSc from Anhui University in 1985 and a MSc from East China Normal University in 1994. After obtaining a PhD from Hangzhou University in 1997, he joined the faculty of Nanjing Normal University as an associate professor of chemistry. He has ever been as a visiting scholar and as a postdoctoral fellow at Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences, Tsing Hua University (Hsinchu, Taiwan, China) and Nanjing University, respectively. He became a full professor at Nanjing Normal University in 2005. His research interests include organometallic chemistry, organic synthetic methodology and organic materials.

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Du, B., Sun, P. Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides. Sci. China Chem. 57, 1176–1182 (2014). https://doi.org/10.1007/s11426-014-5098-7

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  • DOI: https://doi.org/10.1007/s11426-014-5098-7

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