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Fluorescence triggered by ligand-protein hydrophobic interaction

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Abstract

Hydrophobic fluorescence: Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore. The design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein, which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, 250012, China

    ZhenZhen Liu, LuPei Du & MinYong Li

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  1. ZhenZhen Liu
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  2. LuPei Du
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  3. MinYong Li
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Correspondence to MinYong Li.

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Liu, Z., Du, L. & Li, M. Fluorescence triggered by ligand-protein hydrophobic interaction. Sci. China Chem. 56, 1667–1670 (2013). https://doi.org/10.1007/s11426-013-4993-7

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  • DOI: https://doi.org/10.1007/s11426-013-4993-7

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