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The synthesis of benzoxaboroles and their applications in medicinal chemistry

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Abstract

Benzoxaborole, as a versatile scaffold, plays important roles in organic synthesis, molecular recognition and supramolecular chemistry. It is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like properties. Recently, benzoxaboroles were widely applied as antifungal, antibacterial, antiviral, anti-parasite, and anti-inflammatory agents. This review covers the properties, synthetic methods and applications of benzoxaboroles in medicinal chemistry.

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  1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China

    Jiong Zhang, MingYan Zhu, YiNan Lin & HuChen Zhou

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Zhang, J., Zhu, M., Lin, Y. et al. The synthesis of benzoxaboroles and their applications in medicinal chemistry. Sci. China Chem. 56, 1372–1381 (2013). https://doi.org/10.1007/s11426-013-4981-y

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