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Diversity-oriented synthesis of bicyclic ring systems via a conjugate addition/aldol/RCM process

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Abstract

Diversity-oriented synthesis (DOS) has been widely applied in the generation of a large collection of highly functionalized molecules with diverse chemical skeletons. Herein, we report the diversity-oriented synthesis of a series of structurally diverse bicyclic substrates via an efficient tandem conjugate addition/aldol process followed by ring-closing metathesis (RCM). This approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies.

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Correspondence to XiaoGuang Lei.

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Li, C., Li, X., Wang, X. et al. Diversity-oriented synthesis of bicyclic ring systems via a conjugate addition/aldol/RCM process. Sci. China Chem. 56, 337–341 (2013). https://doi.org/10.1007/s11426-012-4805-5

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Keywords

  • diversity-oriented synthesis
  • tandem reaction
  • conjugate addition
  • aldol reaction
  • RCM