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Solvent and catalyst free azo-Michael addition under high-speed vibration milling

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Abstract

Under the high-speed vibration milling conditions, the solvent and catalyst-free azo-Michael addition of chalcone derivatives and amines was found to proceed efficiently in excellent yields at ambient temperature in short reaction time. In most cases, conventional side reactions were avoided and thus quantitative yields were achieved. The influences of the vibration frequency and reaction time on the azo-Michael addition were investigated.

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Authors and Affiliations

  1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310032, China

    YuJin Li, YongWen Cao, FengShuang Xu, WenMing Fang, WuBin Yu, JianHong Jia & JianRong Gao

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  1. YuJin Li
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Correspondence to YuJin Li.

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Li, Y., Cao, Y., Xu, F. et al. Solvent and catalyst free azo-Michael addition under high-speed vibration milling. Sci. China Chem. 55, 1252–1256 (2012). https://doi.org/10.1007/s11426-012-4605-y

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  • DOI: https://doi.org/10.1007/s11426-012-4605-y

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