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Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-αinhibitory activity

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Abstract

Inhibitory effect on tumor necrosis factor-α (TNF-α) production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl substituent have been found to exhibit much more potent TNF-α inhibitory activity than natural sinomenine and other derivatives.

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Authors and Affiliations

  1. State Key Laboratory of Coordination Chemistry and Nanjing National Laboratory of Microstructures; Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China

    Meng Wang, TingTing Zhou, HongZe Liao, ShaoZhong Wang & ZhuJun Yao

  2. Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    LiYan Ma, Chao Bian, Zhao Ma, DongSheng Yin, AiZhong Chen & Bing Sun

  3. State Key Laboratory of Bioorganic and Natural Products Chemistry; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China

    YangTong Lou, HaiBin Zhou, ZhenYu Yang & ZhuJun Yao

Authors
  1. Meng Wang
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  2. LiYan Ma
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  3. YangTong Lou
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  4. Chao Bian
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  5. TingTing Zhou
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  6. HaiBin Zhou
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  7. HongZe Liao
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  8. Zhao Ma
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  9. DongSheng Yin
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  10. AiZhong Chen
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  11. ShaoZhong Wang
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  12. ZhenYu Yang
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  13. Bing Sun
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  14. ZhuJun Yao
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Corresponding authors

Correspondence to Bing Sun or ZhuJun Yao.

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Wang, M., Ma, L., Lou, Y. et al. Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-αinhibitory activity. Sci. China Chem. 55, 2537–2547 (2012). https://doi.org/10.1007/s11426-012-4588-8

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  • DOI: https://doi.org/10.1007/s11426-012-4588-8

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