Abstract
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
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Lin, D., Qian, W., Hilgenfeld, R. et al. Improved synthesis of rupintrivir. Sci. China Chem. 55, 1101–1107 (2012). https://doi.org/10.1007/s11426-011-4478-5
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DOI: https://doi.org/10.1007/s11426-011-4478-5