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Transition metal-catalyzed decarboxylative cross-coupling reactions

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Abstract

Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to replace organometallic reagents enables the decarboxylative cross-coupling reactions to proceed with good selectivities and functional group tolerance. In the present review we summarize the various types of decarboxylative cross-coupling reactions catalyzed by different transition metal complexes. The scope and applications of these reactions are described. The challenges and opportunities in the field are discussed.

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Authors and Affiliations

  1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Rui Shang & Lei Liu

  2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China

    Lei Liu

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  1. Rui Shang
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  2. Lei Liu
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Correspondence to Lei Liu.

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Dedicated to Prof. Ronald Breslow on the occasion of his 80th birthday

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Shang, R., Liu, L. Transition metal-catalyzed decarboxylative cross-coupling reactions. Sci. China Chem. 54, 1670–1687 (2011). https://doi.org/10.1007/s11426-011-4381-0

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