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Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

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Abstract

In this study, we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore, this new nano-interface and Au-MCNT modified electrode could be explored as a rapid, highly sensitive, and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications.

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Authors and Affiliations

  1. State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China

    QingNing Li, XiaoJing Wu, Juan Zhao, ChangYu Wu & XueMei Wang

  2. Medical School, Ningbo University, Ningbo, 315211, China

    QingNing Li

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  1. QingNing Li
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  2. XiaoJing Wu
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  3. Juan Zhao
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  4. ChangYu Wu
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  5. XueMei Wang
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Correspondence to XueMei Wang.

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Li, Q., Wu, X., Zhao, J. et al. Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes. Sci. China Chem. 54, 812–815 (2011). https://doi.org/10.1007/s11426-010-4123-8

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  • DOI: https://doi.org/10.1007/s11426-010-4123-8

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