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Recognition behavior of chiral nanocomposites toward biomolecules and its application in electrochemical immunoassay

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Abstract

The novel nanocomposites were obtained by covalently linking arginine enantiomers with the sidewall of multi-walled carbon nanotubes, and utilized as sensing materials for biomolecular recognition in electrochemical immunoassay. They were characterized by X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and circular dichroism spectroscopy (CD). Nano-gold and Prussian Blue were employed to amplify the analytical signal responses. Prostate specific antibody/antigen and carcinoembryonic antibody/antigen were used as model systems. The results showed that the different configurations of nanocomposites could readily facilitate chiral recognition of antibodies, and D-nanocomposites displayed a larger signal.

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Authors and Affiliations

  1. Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education; College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China

    YingZi Fu, Min Chen, LiLan Wang, Qiao Chen & Juan Zhou

  2. Key Laboratory of Green Chemistry & Technology, Ministry of Education; College of Chemistry, Sichuan University, Chengdu, 610064, China

    Xin Cui

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  1. YingZi Fu
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  2. Min Chen
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  3. Xin Cui
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  4. LiLan Wang
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  5. Qiao Chen
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  6. Juan Zhou
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Correspondence to YingZi Fu.

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Fu, Y., Chen, M., Cui, X. et al. Recognition behavior of chiral nanocomposites toward biomolecules and its application in electrochemical immunoassay. Sci. China Chem. 53, 1453–1458 (2010). https://doi.org/10.1007/s11426-010-4011-2

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  • DOI: https://doi.org/10.1007/s11426-010-4011-2

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