Science China Chemistry

, Volume 53, Issue 6, pp 1346–1351 | Cite as

Structural studies of dicycloplatin, an antitumor supramolecule

  • XuQing Yang
  • XiangLin Jin
  • QinHua Song
  • KaLuo Tang
  • ZhenYun Yang
  • XiaoFeng Zhang
  • YouQi Tang
Articles

Abstract

The solubility and stability of platinum-based anticancer agents have a direct bearing on their activity and toxicity. Much research has been conducted over the past decades in order to prepare drugs such as cisplatin and carboplatin with improved efficacy and reduced toxicity. Based on the premise that supramolecular platinum agents may have superior physicochemical properties, we successfully designed a novel anticancer agent, dicycloplatin, which has proven to be active against a number of human malignancies. The crystal structure of dicycloplatin has been determined. An aqueous solution of dicycloplatin was also studied using electrospray ionization mass spectrometry (ESI-MS). Based on the experimental observations, a model of the structure in aqueous solution is proposed which explains both the higher solubility and higher stability of dicycloplatin compared with carboplatin.

Kwywords

dicycloplatin crystal structure supramolecule anticancer 

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Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • XuQing Yang
    • 1
    • 2
  • XiangLin Jin
    • 2
  • QinHua Song
    • 1
  • KaLuo Tang
    • 2
  • ZhenYun Yang
    • 1
  • XiaoFeng Zhang
    • 1
  • YouQi Tang
    • 2
  1. 1.Beijing Suo Pu Xing Da Pharmaceutical Co. Ltd.BeijingChina
  2. 2.College of Chemistry and Molecular EngineeringPeking UniversityBeijingChina

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