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Preparation of giant unilamellar CdTe quantum dot vesicles and their metabolic pathway in vivo

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Abstract

Glutathione (GSH) capped CdTe quantum dots (QDs) with photoluminescence quantum yields of 61% and the maximum emitting at 601.2 nm were prepared in water phase. Giant unilamellar CdTe quantum dot vesicles (GUVs-CdTe), with diameters larger than 1.5 μm, were obtained using lower-pressure evaporation techniques with soybean lecithin. Compared with other QD liposomes, the entrapment efficiency of GUVs-CdTe for QDs has been significantly improved to 86.3%. After GUVs-CdTe were injected into mice through the tail vein, the fluorescence microscopy of tissue sections showed that GUVs-CdTe could not pass through the blood-brain barrier and air-blood barrier, which were removed mostly by the reticuloendothelial system and were widely distributed in the spleen and the liver. This behavior is the same as the character of the metabolic pathway of giant unilamellar vesicles by intravenous injections in mice.

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Authors and Affiliations

  1. College of Biology and Science, Sichuan Agricultural University, Ya’an, 625014, China

    XianXiang Wang, Zhi San & QianMing Huang

  2. College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, 625014, China

    ZhongKe Yang & Xi Pen

  3. College of Chemistry, Sichuan University, Chengdu, 610041, China

    XianXiang Wang

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  1. XianXiang Wang
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  2. ZhongKe Yang
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Correspondence to XianXiang Wang.

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Wang, X., Yang, Z., San, Z. et al. Preparation of giant unilamellar CdTe quantum dot vesicles and their metabolic pathway in vivo . Sci. China Chem. 53, 1718–1722 (2010). https://doi.org/10.1007/s11426-010-3098-9

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  • DOI: https://doi.org/10.1007/s11426-010-3098-9

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