Abstract
Homochirality in life has always been a driving force in scientific research and natural exploration. It has not been satisfactorily explained, and systematic investigations are necessary. This paper reported a homochiral expression of proteins dependent on the stirring direction of growing media. By controlling the stirring direction clockwise (CW) and anticlockwise (ACW) of the culture medium, proteins with distinct secondary structures were obtained, and D-amino acid may be included in the protein cultured with the stirring direction of ACW. Considering the effect of force fields, which might affect the process of folding and refolding of cellular protein in this report, the control of force fields might be a good way to prepare asymmetric drugs, and the rotational direction of the earth is possibly related to the chirality in primitive life molecules.
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Support from the Major State Basie Research Development Program (Grant No. 2006CB933100) and the National Natural Science Foundation of China (Grant No. 90813019)
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Hu, P., Peng, L., Zhen, S. et al. Homochiral expression of proteins: a discussion on the natural chirality related to the origin of life. Sci. China Chem. 53, 792–796 (2010). https://doi.org/10.1007/s11426-010-0128-6
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DOI: https://doi.org/10.1007/s11426-010-0128-6