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Design of artificial nucleases and studies of their interaction with DNA

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Abstract

The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and molecular biology. This paper reviews recent progress in the investigation of artificial nuclease, including “bifunctional cooperative catalysis”, “dinuclear synergistic catalysis”, “metal-free catalysis”, and especially, the studies of aza-crown ethers as artificial nucleases and their interaction with DNA.

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Authors and Affiliations

  1. State Key Laboratory of Coordination Chemistry, Department of Chemistry, Nanjing University, Nanjing, 210093, China

    JingJing Zhang, Ying Shao, Li Wei, Ying Li, Xin Sheng, Fang Liu & GuoYuan Lu

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  1. JingJing Zhang
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  2. Ying Shao
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  3. Li Wei
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  5. Xin Sheng
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  6. Fang Liu
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Correspondence to GuoYuan Lu.

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Supported by the National Natural Science Foundation of China (Grant Nos. 20872061 & 20372032) and the National Basic Research of China (Grant No. 2007CB925103)

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Zhang, J., Shao, Y., Wei, L. et al. Design of artificial nucleases and studies of their interaction with DNA. Sci. China Ser. B-Chem. 52, 402–414 (2009). https://doi.org/10.1007/s11426-009-0029-8

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  • DOI: https://doi.org/10.1007/s11426-009-0029-8

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