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Specificity of the proteasome cleavage to the antigen protein

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Abstract

In the MHC class I molecule binding antigenic peptides processing and presentation pathway, the ubiquitin-proteasome system plays a key role in degrading the protein substrate. For the purpose of studying the specificities of proteasomal cleavage sites, partial least squares method is used to predict the proteasomal cleavage sites, and the predictive accuracy of the model is 82.8%. The specificities of the cleavage sites and the adjacent positions come from the contribution of the amino acids of the samples to the cleavage sites, showing the information of proteasome interacting with antigen protein. It demonstrates that the proteasome cleaving to target protein is selective, but not random.

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Authors and Affiliations

  1. College of Advanced Science and Technology, Dalian University of Technology, Dalian, 116024, China

    Zhe Song, Tao Liu, ChunBo Jiao, Wei Liu, MingHua Zhu & XiaoGang Wang

  2. Department of Physics, Dalian University of Technology, Dalian, 116024, China

    Wei Liu & YangFan Guo

Authors
  1. Zhe Song
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  2. Tao Liu
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  3. ChunBo Jiao
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  4. Wei Liu
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  5. MingHua Zhu
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  6. YangFan Guo
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  7. XiaoGang Wang
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Correspondence to Wei Liu.

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Song, Z., Liu, T., Jiao, C. et al. Specificity of the proteasome cleavage to the antigen protein. Sci. China Ser. B-Chem. 52, 39–47 (2009). https://doi.org/10.1007/s11426-008-0107-3

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  • DOI: https://doi.org/10.1007/s11426-008-0107-3

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