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Studies on the DNA binding and cleavage activity of a synthesized polyamide containing dipeptide Ser-His

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Abstract

The DNA binding and cleavage activity of a synthetic polyamide containing dipeptide Ser-His has been investigated by spectroscopic techniques, such as electronic absorbance and circular dichroism (CD) spectropolarimetry, as well as gel electrophoresis. The results show that the molecule has a strong interaction with DNA and can improve DNA-cleavage ability about 100 fold as compared with single dipeptide Ser-His.

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Authors and Affiliations

  1. Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Zhang Zhen, Niu MingYu, Ju Yong & Zhao YuFen

Authors
  1. Zhang Zhen
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  2. Niu MingYu
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  3. Ju Yong
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  4. Zhao YuFen
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Correspondence to Zhao YuFen.

Additional information

Supported by the National Natural Science Foundation of China (Grant No. 20572061)

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Zhang, Z., Niu, M., Ju, Y. et al. Studies on the DNA binding and cleavage activity of a synthesized polyamide containing dipeptide Ser-His. Sci. China Ser. B-Chem. 50, 806–811 (2007). https://doi.org/10.1007/s11426-007-0103-z

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  • DOI: https://doi.org/10.1007/s11426-007-0103-z

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