Abstract
Confocal laser scanning microscopy (CLSM) was applied to detect the intracellular [Ca2+] variety of fluorescent intension, with Fluo-3/AM fluorescence loaded in SFSMC. The results show that 10 μmol/L Lacidipine can reduce the frequence which 10 μmol/L 5-HT induced [Ca2+] spark in SFSMC of calcium over loading to 50%, and amplitude to 50% or so. We can draw a conclusion that dihydropyridines calcium antagonists lacidipine can antagonize the release of intracellular [Ca2+] which 5-HT-induced in dose dependent manner.
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Wang, S., Guan, H., Fang, Y. et al. The influence of dihydropyridines calcium antagonists on 5-HT-induced intracellular calcium signal. SCI CHINA SER B 50, 562–567 (2007). https://doi.org/10.1007/s11426-007-0084-y
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DOI: https://doi.org/10.1007/s11426-007-0084-y