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A capacitive sensor based on molecularly imprinted polymers and poly(p-aminobenzene sulfonic acid) film for detection of pazufloxacin mesilate

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Abstract

A novel capacitive sensor for pazufloxacin mesilate (pazufloxacin) determination was developed by electropolymerizing p-aminobenzene sulfonic (p-ABSA) and molecularly imprinted polymers (MPs), which was synthesized through thermal radical copolymerization of metharylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) in the presence of pazufloxacin template molecules, on the gold electrode surface. Furthermore, 1-dedecanethiol was used to insulate the modified electrode. Alternating current (ac) impedance experiments were carried out with a Model IM6e to obtain the capacitance responses. Under the optimum conditions, the sensor showed linear capacitance response to pazufloxacin in the range of 5 ng·mL−1 to 5 μg·mL−1 with a relative standard deviation (RSD) 5.3% (n=7) and a detection limit of 1.8 ng·mL−1. The recoveries for different concentration levels of pazufloxacin samples varied from 94.0% to 102.0%. Electrochemical experiments indicated the capacitive sensor exhibited good sensitivity and selectivity and showed excellent parameters of regeneration and stability.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China

    Zhou Lu, Ye GuangRong, Yuan Ruo, Chai YaQin & Chen SuMing

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  1. Zhou Lu
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  2. Ye GuangRong
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  3. Yuan Ruo
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  4. Chai YaQin
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  5. Chen SuMing
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Additional information

Supported by the National Natural Science Foundation of China (Grant No. 20675064), the Natural Science Foundation of Chongqing City (Grant No. CSTC-2004BB4149 and 2005BB4100) and High Technology Project Foundation of Southwest University (Grant No. XSGX02).

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Zhou, L., Ye, G., Yuan, R. et al. A capacitive sensor based on molecularly imprinted polymers and poly(p-aminobenzene sulfonic acid) film for detection of pazufloxacin mesilate. SCI CHINA SER B 50, 547–553 (2007). https://doi.org/10.1007/s11426-007-0035-7

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  • DOI: https://doi.org/10.1007/s11426-007-0035-7

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