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A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty

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Abstract

This paper discusses the associations between traits and haplotypes based on FI (fluorescent intensity) data sets. We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. “GenoSpectrum”). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotype-based logistic regression model. Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors.

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Authors and Affiliations

  1. School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024, China

    Zhu Wensheng & Guo Jianhua

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  1. Zhu Wensheng
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  2. Guo Jianhua
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Zhu, W., Guo, J. A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty. SCI CHINA SER A 49, 130–144 (2006). https://doi.org/10.1007/s11425-005-0147-5

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  • DOI: https://doi.org/10.1007/s11425-005-0147-5

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