Journal of Systems Science and Complexity

, Volume 23, Issue 5, pp 896–905 | Cite as

Nonlinear Langevin model with product stochasticity for biological networks: The case of the Schnakenberg model

Article

Abstract

Langevin equation is widely used to study the stochastic effects in molecular networks, as it often approximates well the underlying chemical master equation. However, frequently it is not clear when such an approximation is applicable and when it breaks down. This paper studies the simple Schnakenberg model consisting of three reversible reactions and two molecular species whose concentrations vary. To reduce the residual errors from the conventional formulation of the Langevin equation, the authors propose to explicitly model the effective coupling between macroscopic concentrations of different molecular species. The results show that this formulation is effective in correcting residual errors from the original uncoupled Langevin equation and can approximate the underlying chemical master equation very accurately.

Key words

Langevin equation master equation noise Schnakenberg model 

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Copyright information

© Institute of Systems Science, Academy of Mathematics and Systems Science, CAS and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghaiChina
  2. 2.Department of BioengineeringUniversity of Illinois at ChicagoChicagoUSA

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