How Should We Define Clinically Significant Outcome Improvement on the iHOT-12?

Abstract

Background

There is increased emphasis on efficiently administering patient-reported outcome measures (PROMs). The International Hip Outcome Tool-12 (iHOT-12) is a short-form version of the iHOT-33, and relatively little is known about clinically significant outcomes using the iHOT-12.

Questions/Purposes

The purpose of this study was to define minimal clinically important difference (MCID) and patient acceptable symptomatic state (PASS) for the iHOT-12 and to identify predictors for achieving these psychometric end points in patients undergoing arthroscopic treatment of femoroacetabular impingement (FAI).

Methods

Data was prospectively collected and retrospectively analyzed as part of an institutional hip preservation repository. One hundred and twenty patients were included; mean age and body mass index (BMI) were 38.7 years and 25.9, respectively. A majority of patients were female (67.5%) and white (81.7%) and participated in recreational sports (79.2%). The iHOT-12 was administered pre-operatively and at 1-year follow-up to patients undergoing primary hip arthroscopy for FAI. The following anchor question was also asked at 1-year follow-up: “Taking into account all the activities you have during your daily life, your level of pain, and also your functional impairment, do you consider that your current state is satisfactory?” MCID was calculated using a distribution-based method. Receiver-operating characteristic analysis with area under the curve was used to confirm the significance of the PASS threshold.

Results

Mean iHOT-12 scores improved from 35.6 at pre-operative assessment to 70.7 at 1-year follow-up. Patients indicating satisfaction with their outcome improved from 37.5 pre-operatively to 79.0 at 1-year follow-up. MCID value for the iHOT-12 was 13.0. The PASS threshold was 63.0, indicating an excellent predictive value that patients scoring above this threshold were likely to have met an acceptable symptom state. Worker’s compensation patients and those with increased BMI were less likely to achieve PASS; lower pre-operative iHOT-12 score was predictive for achieving MCID, and achieving MCID was predictive for achieving PASS.

Conclusion

This is the first study to define PASS and MCID for the iHOT-12, which measures clinically significant outcome improvement comparably to that of other commonly used hip PROMs. As its use becomes more widespread, the iHOT-12 data-points presented in this study can be used to determine clinically significant improvement of patient-reported outcomes.

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Authors

Corresponding author

Correspondence to Shane J. Nho MD, MS.

Ethics declarations

Conflict of Interest:

Benedict U. Nwachukwu, MD, Brenda Chang, MPH, Edward C. Beck, MPH, William H. Neal, BS, and Kamran Movassaghi, MD, declare that they have no conflicts of interest. Shane J. Nho, MD, MS, reports research support from Allosource, Arthrex, Inc., Athletico, DJ Orthopedics, Linvatec, Miomed, Smith & Nephew, and Stryker; editorial board membership from American Journal of Orthopedics; board or committee membership from American Orthopaedic Society for Sports Medicine and Arthroscopy Association of North America; personal fees from Ossur; and publishing royalties from Springer, outside the submitted work. Anil S. Ranawat, MD, reports personal fees from Arthrex, Smith & Nephew, and Stryker, outside the submitted work.

Human/Animal Rights:

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2013.

Informed Consent:

Informed consent was waived from all patients included in this study.

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Additional information

Level of Evidence: Level IV: Case Series.

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Appendix

Appendix

Table 5 The International Hip Outcome Tool-12 (iHOT-12) Survey

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Nwachukwu, B.U., Chang, B., Beck, E.C. et al. How Should We Define Clinically Significant Outcome Improvement on the iHOT-12?. HSS Jrnl 15, 103–108 (2019). https://doi.org/10.1007/s11420-018-9646-0

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Keywords

  • hip
  • femoroacetabular impingement
  • MCID
  • PASS
  • patient-reported outcome measures (PROMs)